Specifically, we are currently testing an AMPK activator as novel therapy for the aging right heart. Skeletal muscle dysfunction in heart failure Heart failure is a systemic disease, with peripheral ...

Announcing a new article publication for BIO Integration journal.   Diabetes, a common metabolic condition, poses a substantial health burden worldwide. To revolutionize diabetes management, enhance ...

Previous research has shown that mammals accumulate LCA during calorie restriction and it activates a key molecule involved in metabolism called AMP-activated protein kinase, or AMPK. AMPK ...

Moreover, the mechanistic study elegantly uncovered the molecular pathway underlying LCA-mediated AMPK activation,” wrote Xu Chen at the University of California San Diego. Liu Cao, Health Sciences ...

Why AMPK Is Crucial AMPK (adenosine monophosphate-activated protein kinase) is often dubbed the “metabolic master switch”: Inhibits Excess Fat Storage: AMPK works to block carbs from turning ...

Background and aims The transcription factor sex-determining region Y-related high-mobility group-box gene 9 (SOX9) plays a critical role in organ development. Although SOX9 has been implicated in ...

CR activates adenosine monophosphate (AMP)-activated protein kinase (AMPK), an enzyme that helps cells maintain energy balance. AMPK regulates several signalling pathways that delay aging ...