Monoclonal antibodies, or mAbs, are important tools in medicine. These laboratory-made proteins are widely used in treatments ...

Here, we discuss strategies to select the best therapeutic antigen targets, to optimize the structure of IgG antibodies and to design related or new structures with additional functions.

This study uncovers a unique broad neutralization mechanism against rotavirus, where antibody 7H13 destabilizes the partial structure of the viral VP4 spike by acting on a critical residue switch ...

All nine macaques given the control developed severe disease when exposed to bird flu, as did all given the smallest dose of ...

Antivenoms are the most effective therapeutic option, but they are made from animal-derived antibodies, which can trigger serious allergic reactions. Additionally, only a few of these antibodies ...

A prophylactic antibody-based immune therapy protects monkeys against severe disease caused by H5N1 avian flu, University of Pittsburgh and NIH Vaccine Research Center researchers report today in ...