Chronic exposure to hyperglycemia can lead to cellular dysfunction that may become irreversible over time, a process that is termed glucose toxicity. Our perspective about glucose toxicity as it ...

Following a filing revealing its intent to go public in the US on 6 January, artificial pancreas maker Beta Bionics has now ...

Diabetes affects an estimated 415 million people worldwide, with type 2 diabetes (T2D) accounting for about 90% of these cases. T2D develops when the pancreas cannot produce enough insulin, the ...

This is a useful study that seeks to address the role of the TET family of DNA demethylation enzymes in pancreatic beta cell senescence in the context of type 2 diabetes (T2DM). Although the concepts ...

Increased levels of glucose in the circulation lead to increased glucose uptake into pancreatic beta cells through GLUT2, a glucose transporter. Increased intracellular glucose then leads to ...

Findings suggest targeting neuro-immune pathway could lead to strategies for managing diabetes, obesity or some types of ...

For example, beta cells secrete insulin in response to increased blood glucose levels, and this stimulates cells to take up glucose, an essential step in energy homeostasis. In contrast ...

MHH team aims to intervene in the autoimmune process and stop the destruction of insulin-producing beta cells in the pancreas ...

New in vivo preclinical data announced today, demonstrate that icovamenib, in combination with semaglutide showed additional 11.5% body weight ...