Recent evidence that X4 variants can sometimes evolve in R5 HIV-1-infected hu-PBL-SCID mice treated with derivatives of the chemokine CCR5 ligand RANTES may not be predictive for clinical ...

What was Prof He trying to do? Prof He was targeting a gene called CCR5. It is a set of genetic instructions that are important for how the immune system functions. However, they are also the ...

Among the CCR5 inhibitors developed so far ... Importantly, the interaction between CXCR4 and its ligand SDF-1 is involved in various disease conditions, such as cancer cell metastasis, leukemia ...