Recent evidence that X4 variants can sometimes evolve in R5 HIV-1-infected hu-PBL-SCID mice treated with derivatives of the chemokine CCR5 ligand RANTES may not be predictive for clinical ...

Among the CCR5 inhibitors developed so far ... Importantly, the interaction between CXCR4 and its ligand SDF-1 is involved in various disease conditions, such as cancer cell metastasis, leukemia ...