HIV-1 entry into cells is an attractive target for new antiviral ... include two co-receptors on the cell surface—CCR5 and CXCR4—which together with CD4 mediate virus binding and membrane ...

Experiments using cells that expresses both CXCR4 and CCR5, such as human peripheral blood mononuclear cells, rarely result in the selection of drug-resistant viruses that change coreceptor usage.

Data underscore the vast potential of allogeneic, non-HLA matched, T regulatory cell therapy program in addressing diseases driven ... Founder of Cellenkos. "CK0804 is a CXCR4-enriched Treg cell ...