HIV-1 entry into cells is an attractive target for new antiviral ... include two co-receptors on the cell surface—CCR5 and CXCR4—which together with CD4 mediate virus binding and membrane ...

Experiments using cells that expresses both CXCR4 and CCR5, such as human peripheral blood mononuclear cells, rarely result in the selection of drug-resistant viruses that change coreceptor usage.

This effect is associated with increased infiltration and activation of cytotoxic T lymphocytes and prolonged survival. These new insights into the role of CXCR4 in dendritic cells may help ...