to preserve cardiac cell homeostasis and maintain the organ mass required to appropriately handle the cardiac output demanded. Contractile myocytes function as the sensor mechanism that ...
Protein kinase C, in particular PKCα, also worsens calcium cycling and contractility ... of heart disease. Pathological stress from cardiovascular disease stimulates hypertrophy of heart cells ...
Because humans are much larger than newts and salamanders, we needed more heart contraction to maintain optimum blood pressure and circulation. MacLellan suggests that it might be possible to get the ...
Patches of beating, lab-grown muscle sewn into failing hearts can keep patients alive for years while they wait for a transplant, scientists have shown. In a major breakthrough, 15 patients suffering ...
and genes that have organotypic specificity in cardiac ECs and the endocardium. Interestingly, hiPS-ECs in co-culture expressed myofibrillar contractile genes, of which most were not observed in ...