The self-sustaining regulatory mechanisms that fuel the senescence programme may also involve negative-feedback loops, as was shown for C/EBP, which blocks promoters of cell-cycle-promoting genes ...

Immortalized cell lines are derived from cancer cells or genetically modified to overcome senescence, allowing them to proliferate indefinitely ... regenerative medicine, and disease modeling. 3D cell ...

F. Passos et al., "Mitochondrial dysfunction accounts for the stochastic heterogeneity in telomere-dependent senescence," PLoS Biology, 5:1138, 2007. (Cited in 31 papers) The study: To investigate why ...

The latest findings on the interaction between cell death and cellular senescence in cancer and their pathophysiological significance have been reviewed by a team from Osaka Metropolitan ...

Experiments show that IL-23R levels in the bloodstream increase with age and can decrease, reflecting senescent cell clearing, with senolytic therapies. Cellular senescence occurs when cells stop ...

This is a useful study that seeks to address the role of the TET family of DNA demethylation enzymes in pancreatic beta cell senescence in the context of type 2 diabetes (T2DM). Although the concepts ...