In an emerging model of quiescence, whether CDC6 is loaded on the chromatin or not might represent an important distinction between cells that will continue through G1 to S phase versus those that ...
In tumoral cells, the modulation of the G1/S phases of cell cycle is destabilized by amplification and high expression of cyclin E (CCNE) or by mutation or loss of retinoblastoma 1 (RB1) gene. Cancer ...