One avenue for this ambition is cell receptors, which function like ignition slots on a cell, requiring keys—such as specific hormones, drugs, or antigens—to start up specific cellular activities.

G protein-coupled receptors (GPCRs), also called seven-transmembrane receptors ... it remains largely unknown how exactly distinct ligands drive discrete signaling pathways in the cellular context.

Diabetes mellitus causes stimulation of receptor mediated signalling pathways, that lead to outcomes resulting in organ fibrosis such as the kidneys, heart and vessels. Nearly 25% of diabetic people ...

Proteins are life's engines, powering processes like muscle movement, vision, and chemical reactions. Their ...

Among the five existing somatostatin receptor (sst) subtypes, sst2A is the most frequently expressed in these tumours. However, little information is available about the cellular location of sst2A in ...

T-cell therapy, originally developed for haematological malignancies, has recently emerged as a promising therapy for patients with autoimmune diseases. By selectively depleting CD19-positive B-cells, ...

With viral disease emergence expected to accelerate, preparing for possible future pandemics is paramount. Beyond saving lives during outbreaks, robust pandemic preparedness safeguards economies, ...

This Research Topic aims to collect high-quality review and original research articles, investigating the P2X7 receptor and its involvement in the molecular and cellular mechanisms underlying ...

Sigma-2 receptor modulation using exogenous ligands reduces cellular damage associated with central nervous system degeneration in age-related pathologies such as Alzheimer’s disease, Parkinson’s ...