The role of endosome and lysosome dysfunction in neurodegenerative disease progression • The influence of exosomes on neurodegenerative disease progression • Therapeutic strategies targeting ...

(6) Lysosomes directly take up mitochondria by the lysosomal membrane invagination. (7) Endosome/pre-lysosome directly ‘hit and run’ with mitochondria or MDV to form mitochondria-lysosome ...

Damaged lysosomes are repaired by a lipid-based signaling pathway dubbed PITT that could be targeted to treat neurodegenerative disease, its discoverers say. Holly Barker is a freelance journalist ...

Endocytosis and degradation of the membrane receptors in the lysosome controls the activation of intracellular signaling pathways, but the mechanisms that control the endocytosis ... US show that ...

Upon uptake, proteins and soluble components from the extracellular space pass through endosomes before fusing and/or maturing to form lysosomes. During the endosome–lysosome transition ...

A recent study published in eLife has uncovered a crucial mechanism in cellular material management: endosome maturation ... late endosomes and eventually to lysosomes, where they are fully ...

2015; Luo et al., 2016), and the mechanisms underlying the vacuolization effects differ. For example, 3C protease of hepatitis A virus (3Cpro) has induced numerous non-acidic cytoplasmic vacuoles, ...

Second, following their cellular uptake, nanoparticles are trapped in endosomes/lysosomes, where siRNA would ... “proton sponge effect”, destabilizing endosome membrane, and hydrophobic modification ...