(6) Lysosomes directly take up mitochondria by the lysosomal membrane invagination. (7) Endosome/pre-lysosome directly ‘hit and run’ with mitochondria or MDV to form mitochondria-lysosome ...

Endocytosis and degradation of the membrane receptors in the lysosome controls the activation of intracellular signaling pathways, but the mechanisms ... US show that hepatocyte growth factor ...

Damaged lysosomes are repaired by a lipid-based signaling pathway dubbed PITT that could be targeted to treat neurodegenerative disease, its discoverers say. Holly Barker is a freelance journalist ...

Endosomes receive cargo (proteins and lipids) from both the biosynthetic and the endocytic pathways. For instance, proteins that are destined for the vacuoles/lysosomes are synthesized at the ...

However, researchers have now found a new pathway involving MLRO. MLRO is a unique organelle formed by the fusion of a mitochondrion and a lysosome, a cellular "garbage disposal" unit. This hybrid ...

The hypothesis is that intraneuronal Tau accumulation acts as a lysosomal stress signal to activate TFEB and V-ATPase expression. Further, effective TFEB/V-ATPase signaling is critical for lysosomal ...