During the endosome–lysosome transition, the compartmental pH drops, which is conducive to the function of lysosomal acid hydrolases. Damaged lysosomes are eliminated by lysophagy, yet the ...

The Lysosomal Metabolomics and pH Core’s overarching goal is to understand the mechanistic link between lysosomal activity and aging in Alzheimer’s Disease. To accomplish this, the core will support ...

A recent study published in eLife has uncovered a crucial mechanism in cellular material management: endosome maturation ... late endosomes and eventually to lysosomes, where they are fully ...