The epigenetic memory of a cell defines the set of modifications to the cell's deoxyribonucleic acid (DNA) that do not alter the DNA sequence, and have been inherited from the cell from which it ...

Devised in the 1940s by the biologist C.H. Waddington, the epigenetic landscape is a metaphor for how gene regulation modulates cellular development. As a scientific model, it fell out of use in the ...

Cancer’s epigenetic landscape, a labyrinthine tapestry of molecular modifications, has long captivated researchers with its profound influence on gene expression and cellular fate. This review ...

A new example of the power of bioinformatics is presented in the study published in the journal Leukaemia part of the Nature group ... The study makes epigenetic maps of over 200 cell lines ...

15 The adaptive nature of some epigenetic modifications and their transgenerational inheritance have also contributed to epigenetics being labelled as revolutionary. These features have revived the ...

This review addresses the steps involved in resetting the epigenetic landscape during reprogramming. Apparently, defined events occur during the course of the reprogramming process. Immediately, upon ...

the team observed that DNA breaks and subsequent repair lead to the erosion of the epigenetic landscape. This means that while, normally, cells have genomic regions with high levels of histones bound ...

This review summarises both current clinical trial activities and discovery programmes initiated throughout the biopharma landscape, and critically discusses the chances, hurdles and limitations of ...