The cytoplasmic portion ... the apical end of each cell faces out into the environment — such as the inner cavity or lumen of the gut. The side-to-side junctions that link epithelial cells ...

and interactions between epithelial cells and host microbiota or pathogens. Traditional methods produce organoids with a “basolateral-out” morphology, which prevents scientists from accessing the ...

the epithelial layer of the crypt ... in detail, the goblet cell nucleus is colored in dark blue and the apical portion, expanded with mucin-secreting granules, which extends into the intestinal ...

The spatial organization of the cells that form a tissue is also central to the tissue's function and survival. This organization depends in part on ... Mammalian epithelial cells also turn ...

which means that they have a monolayer of epithelial cells with fluid inside. The cells interact with the matrix on the basal side, and things such as nutrients and drugs interact with the tissue ...