Osteoarthritis disproportionally affects postmenopausal women, and a biological mechanism for why this occurs has been largely unkown, hindering development of effective treatments. That is in part ...

A groundbreaking 24-week trial compares topical treatments for dermatoporosis-related skin fragility, revealing improvements ...

Topical formulation repairs skin thinning, fragility and bruising as a result of aging, according to a press ...

They discovered that menopause-induced loss of estrogen and progesterone promotes extracellular matrix degradation and chondrocyte deterioration, while restoring these hormones to pre-menopausal ...

Hepatic fibrosis is a reversible wound healing response characterized by accumulation of extracellular matrix (ECM), or ... an array of changes including degradation of the normal ECM of liver ...

OA is characterized by degradation of the cartilage tissue in joints. Cartilage comprises two major components, the extracellular matrix (the surrounding proteins that provide structure ...

As noted in the abstract of this paper, dermal fibroblasts orchestrate the synthesis and degradation of extracellular matrix components, which is crucial for skin homeostasis. Alterations in the ...

Osteoarthritis (OA) is a condition that disproportionally affects postmenopausal women, and the millions affected can attest to the pain, reduced ...

As noted above, stellate cell activation is the central event in hepatic fibrosis. Activation consists of 2 major phases: (1) initiation (also called apreinflammatory stage) and (2) perpetuation ...