G protein-coupled receptors (GPCRs) are the largest group of membrane proteins. GPCRs' primary function is to convert a wide range of extracellular stimuli, including biogenic amines, peptides ...

In this diagram of G-protein-coupled receptor activation ... These activated subunits can act on ion channels in the cell membrane, as well as cellular enzymes and second messenger molecules ...

The discovery of G protein-coupled receptor (GPCR) heteromers has revealed a new level of complexity in their functional characteristics. This review explores a variety of methodologies and live ...

Adhesion G protein-coupled receptors (GPCRs) are a group of cell-surface sensors associated with many body functions and diseases. However, they are not yet sufficiently understood to be exploited for ...

The 2012 Nobel Prize for Chemistry has been awarded to Robert Lefkowitz and Brian Kobilka for groundbreaking discoveries that reveal the inner workings of G-protein-coupled receptors. Professor David ...

Membrane receptors fall into three major classes: G-protein-coupled receptors, ion channel receptors, and enzyme-linked receptors. The names of these receptor classes refer to the mechanism by ...

This family is now known as G-protein-coupled receptors, and the studies by Lefkowitz and Kobilka have been crucial to understanding how they function. The insights have been ...

Adhesion GPCRs are a group of cell-surface sensors associated with many body functions and diseases. However, they are not yet sufficiently understood to be exploited for therapies. Scientists have ...

Proteins are life's engines, powering processes like muscle movement, vision, and chemical reactions. Their environments—water, lipid membranes, or other condensed phases—are critical to their ...