Innovative designs of GPCRs with enhanced signaling and stability offer new insights for drug discovery and synthetic biology ...

Cells have proteins called receptors that bind to signaling molecules and initiate ... Membrane receptors fall into three major classes: G-protein-coupled receptors, ion channel receptors, and ...

EPFL researchers have developed a computational method to explicitly consider the impact of water while designing membrane receptors with enhanced stability and signaling, paving the way for novel ...

Proteins are life's engines, powering processes like muscle movement, vision, and chemical reactions. Their ...

Proteins are life's engines, powering processes like muscle movement, vision, and chemical reactions. Their environments-water, lipid membranes, or other condensed phases-are critical to their ...

Proteins are essential macromolecules that play a crucial role in virtually all biological processes. They are the building blocks of life, performing a wide range of functions within organisms, from ...

My group focuses on understanding cell signaling pathways primarily linked with the ubiquitin ... we employ and develop multiple quantitative proteomics workflows to examine how flux in signaling ...

7 refine our understanding of the signaling effects of oncogenic ... network by measuring changes in protein-specific phosphorylation in pancreatic cells with pharmacologically inhibited ERK.