A number of cell surface and nuclear receptors mediate their actions via dimerization. While this has been well established, the dimerization of G-protein coupled receptors (GPCRs) (that ...

Innovative designs of GPCRs with enhanced signaling and stability offer new insights for drug discovery and synthetic biology ...

G protein-coupled receptors (GPCRs) are integral membrane proteins with seven membrane-spanning helices. Upon binding to a ligand – which can range from small molecules like cyclic AMP to ...

Adhesion G protein-coupled receptors (GPCRs) are a group of cell-surface sensors associated with many body functions and diseases. However, they are not yet sufficiently understood to be exploited for ...

Advancements in Physiology to Drive Market Demand Application of G-protein coupled receptors (GPCRs) in the domain of physiology has emerged as an important dynamic of market growth. Regulation of the ...

They also realized that the β-adrenergic receptor was one of many in a whole family of receptors that function in the same way. This family is now known as G-protein-coupled receptors, and the studies ...

Olfactory receptors, classified as G-protein coupled receptors (GPCRs), have been a subject of scientific inquiry since the early 1950s. Historically, investigations into the sensory mechanisms of ...

The discovery of G protein-coupled receptor (GPCR) heteromers has revealed a new level of complexity in their functional characteristics. This review explores a variety of methodologies and live ...

The 2012 Nobel Prize for Chemistry has been awarded to Robert Lefkowitz and Brian Kobilka for groundbreaking discoveries that reveal the inner workings of G-protein-coupled receptors. Professor David ...

Adhesion G protein-coupled receptors are a large class of membrane proteins that detect chemical and mechanical stimuli in the body. The GAIN domain ...

Kappa opioid receptor is a G protein-coupled receptor (GPCR), whose activation mediates guanosine diphosphate ... co-expressing the different pairs of fusion proteins were prepared using the pantropic ...

Adhesion GPCRs are a group of cell-surface sensors associated with many body functions and diseases. However, they are not yet sufficiently understood to be exploited for therapies. Scientists have ...