But how does this happen? "It is as if G-protein signaling causes the channel to need more 'persuasion'—in terms of stronger electrical signals—to open. In our study, we describe at the ...

Thus, receptors can initiate signals to both traditional and G protein–independent pathways and can control the relative activity of these cascades according to the chemical nature of the bound ...

Other signaling molecules must move much farther ... Membrane receptors fall into three major classes: G-protein-coupled receptors, ion channel receptors, and enzyme-linked receptors.

Innovative designs of GPCRs with enhanced signaling and stability offer new insights for drug discovery and synthetic biology ...

EPFL researchers have developed a computational method to explicitly consider the impact of water while designing membrane receptors with enhanced stability and signaling, paving the way for novel ...

Proteins are life's engines, powering processes like muscle movement, vision, and chemical reactions. Their environments-water, lipid membranes, or other condensed phases-are critical to their ...