CcpA and TnrA are the global regulators for carbon metabolism and nitrogen metabolism ... 2-oxoglutarate and glutamate. Here, the latest knowledge on the control of these key intersections ...
glutamate, aspartate, and serine). This potential link with evolutionary history is consistent with Morowitz's 20 claim that intermediary metabolism recapitulates the evolution of biochemistry.
In particular, the work reveals that modulating glutamine metabolism is a potential therapeutic ... the removal of ammonium by combining glutamate with the ammonium to produce glutamine.