glutamate, aspartate, and serine). This potential link with evolutionary history is consistent with Morowitz's 20 claim that intermediary metabolism recapitulates the evolution of biochemistry.

In particular, the work reveals that modulating glutamine metabolism is a potential therapeutic ... the removal of ammonium by combining glutamate with the ammonium to produce glutamine.

More information: Joeri Bordes et al, Sex-specific fear acquisition following early life stress is linked to amygdala and hippocampal purine and glutamate metabolism, Communications Biology (2024).

LIU and his team shed light on the crucial role of glutamate tRNA fragments in brain aging and Alzheimer's disease, offering new insights for delaying cognitive decline. The researchers designed ...