The original and simulated structural conformations were visualized and presented using ChimeraX (v1.5). Results: We present an allelic atlas of immunoglobulin heavy chain (IgH) variable regions, ...

Some animals use additional strategies to achieve structural complexity in the antibody combining site, and one of the most interesting of these is the formation of ultralong heavy chain ...

The recent conference, `Alpha 1-antitrypsin deficiency and ... reported that mutant or unassembled immunoglobulin M μ-heavy chains accumulate within ER-derived vesicles, called Russell bodies ...