to mevalonate is the major point of regulation on the pathway to cholesterol (Fig. 1). The discovery of statins is due to a substantial extent to the pioneer work by the Japanese researcher Akira ...

However, the inhibition of the mevalonate pathway decreases the formation of coenzyme Q10 (CoQ10) within the body. It has been a long-standing theory that statin-associated muscle pain (myalgia ...

The mevalonate pathway is a crucial metabolic route that produces important biological molecules, including cholesterol and isoprenoids. Farnesyl diphosphate synthase (FPPS) is a key enzyme in ...