In 1961 the structure of one protein, myoglobin ... It proved difficult to decide by refolding experiments whether or not proline isomerization explains the two unfolded forms of RNase A because ...

A protein's function directly depends on its folded structure. Additionally ... which is rich in the amino acid proline. This domain contains a binding site with a high affinity for calcium ...

Incorporating the amino acid building block proline into the nascent protein molecule presents a particular challenge for the cell during protein biosynthesis. Due to its rigid structure ...