Cells maintain a continuous free pool of ubiquitin that can be conjugated onto target proteins to mark them for degradation by the proteasome. Now, in Cell, Finley and colleagues show that the ...

Prokaryotic proteasomes are a rare breed: only the Archaea and a few members of the Actinomycetes have been shown to possess a proteasome. But now, this exclusive club has a new member — two ...

More information: Jin Ju Lim et al, Pharmacological inhibition of USP14 delays proteostasis-associated aging in a proteasome-dependent but foxo-independent manner, Autophagy (2024). DOI: 10.1080 ...