It appears that there are two pathways of ... Unusually, the degradation of Rpn4 is largely ubiquitin independent, which highlights its function as a dedicated proteasome sensor and, furthermore ...

Selective protein degradation by the ubiquitin–proteasome pathway is a fundamental regulatory strategy that fulfils essential roles in various cellular processes. In recognition of the central ...

Her laboratory focuses on elucidating; (i) biological functions of active dissociation via these chaperones, (ii) mechanisms of an assembly-coupled degradation via an oncorpotein and assembly ...

“It turns out that this pathway can be targeted ... the signal for it be destroyed by the proteasome. Although this revealed how pVHL marks HIF for degradation, how the interaction of the ...