In 2013, Jason McLellan and his colleagues determined the molecular structure of RSV's F glycoprotein in the prefusion conformation (the shape it takes before the virus infects a cell).

This is the RSV fusion glycoprotein is shown (left) in its pre-fusion state in complex with an antibody (red and white ribbon) and (right) in its post-fusion shape. Disclaimer: AAAS and EurekAlert!

RSV F proteins sit on the viral surface ... syncytial virus matrix protein lattice and its coordination with fusion glycoprotein trimers, Nature Communications (2024). DOI: 10.1038/s41467-024 ...

Similar to respiratory syncytial virus (RSV), immunizing mice with pre-fusion F protein elicits higher ... Stable trimeric pre-fusion F protein Post-fusion F protein Glycoprotein G These antigens have ...

There is as yet no licensed vaccine. SynGEM, a novel intranasal subunit vaccine based on the RSV F glycoprotein linked to an immunostimulatory bacterium-like-particle carrier, was previously shown in ...

New Delhi: The Subject Expert Committee (SEC) functional under the Central Drug Standard Control Organisation (CDSCO) has ...

ucl.ac.uk Respiratory syncytial virus (RSV) is the most common single cause of respiratory hospitalisation ... There are many vaccines under development, mostly based on the surface glycoprotein F ...

As an enveloped negative-sense single-stranded RNA virus of the family Pneumoviridae and the order Mononegavirales, RSV has 10 genes coding for 11 proteins, including the G glycoprotein and the fusion ...

The vaccine comprises an mRNA sequence that encodes the RSV F glycoprotein, which is essential for the virus' ability to infect host cells. The drug also received US Food and Drug Administration ...

This work involved studies in mice to define T cell function and regulation, and evaluation of RSV F glycoprotein conformational determinants of antigenicity. RSV F is a class 1 fusion protein and ...