Figure 3: Timeline of clinical disease course and therapy ... such as isolated plaques of morphea or linear scleroderma, as it exhibits a contiguous spread of hard and thick skin over a wide ...

Morphea is a localized form of scleroderma that leads to excessive ... some patients have a form of the disease called linear ...

Scleroderma is classified as a rare, autoimmune, collagen-vascular disease of unknown etiology that can be difficult to diagnose and treat. Its onset can be insidious or rapid; the symptoms range ...

Diffuse scleroderma (extensive skin thickening proximal to the elbows and knees along with internal organ involvement) Scleroderma sine sclerosis (Raynaud's phenomenon and internal involvement ...

Scleroderma is caused by an excess of collagen produced by the immune system, and often causes hardening and thickening of the skin and organs. Scleroderma symptoms can range from mild to life ...