这些作者在这些家谱中发现了意想不到的突变遗传模式，揭示了一些DNA损伤可以在多轮细胞分裂中持续存在而无法修复。这在造血干细胞中尤为明显，其中15%至20%的突变是由一种特定类型的DNA损伤引起的，这种损伤平均持续两到三年，在某些情况下甚至更长。这意味着在细胞分裂过程中，每次细胞试图复制受损的DNA时，都会犯不同的错误，导致单一DNA损伤源引起的多种不同突变。

New research shows persistent DNA lesions in stem cells contribute to mutations, with links to blood cancers and external ...

In a groundbreaking shift in our understanding of mutations, researchers have discovered types of DNA damage in healthy cells ...

This segregates the DNA most recently replicated, and therefore most error-prone, into cells destined for differentiation – which, in highly renewable tissues, are soon shed. (SSC indicates somatic ...

Scientists at the Wellcome Sanger Institute uncovered DNA damage that can persist for years, evading repair mechanisms and ...

The pair had helped identify a still-unnamed disease, which they had tied to a particular gene and to a particular somatic mutation—a genetic change that had not been passed down from a parent and was ...

Once this number surpasses 150 repeats, the cells become dysfunctional and die ... then even modestly slowing somatic expansion might substantially postpone HD symptom onset.” ...