Unrelated human MSCs did not elicit T-cell activation in vitro and suppressed T-cell activation by Tuberculin and unrelated allogeneic lymphocytes in a dose-dependent manner. Cell-free MSC culture ...

Figure B. Pale necrotic lesion of lymph node shows small karyorrhectic debris and polymorphous cell population of surrounding cells (histiocytes, lymphocytes, plasmacytoid monocytes). (H&E x 400 ...

Researchers found that bioengineered CAR-T cells when mixed with other immune cells can "donate" proteins, suggesting ...

To investigate the spatiotemporal organisation of T cell signalling in a physiologically relevant context, we activate murine TCR transgenic T cells ex vivo with professional APCs and antigenic ...

Two main sub-types of immune cells are T cells and macrophages. T cells are designed to recognise the molecular signatures of particular proteins, such as those from bacteria, in order to activate an ...

More information: Hongxing Shen et al, HIF1α-regulated glycolysis promotes activation-induced cell death and IFN-γ induction in hypoxic T cells, Nature Communications (2024). DOI: 10.1038 ...

Immune cells called regulatory T cells have long been known for their role in countering inflammation. In the setting of ...

The researchers engineered cancer cells to re-express Parkin and found that Parkin contributes to the production of interferons, which activate and attract T cells to fight the tumor. The findings ...

As noted above, stellate cell activation is the central event in hepatic fibrosis. Activation consists of 2 major phases: (1) initiation (also called apreinflammatory stage) and (2) perpetuation ...