CD8 + T cell exhaustion is defined by a unique transcriptional and epigenetic profile that is important to understand for the generation of immunotherapies to treat cancer. Research now shows how ...

Traditional epigenetic clocks keep track of chronological time ... Similarly, said Masopust, “We could learn about the regulation of [T cell] exhaustion in a different way; maybe we could apply this ...

Findings indicate that altering glucose metabolism in T cells boosts their therapeutic potential against melanoma, paving the way for improved immunotherapies.

"These epigenetic differences can be ... especially in solid tumor contexts, where exhaustion plays a large part in limiting anti-tumor T cell responses." ...

leads to T cell exhaustion (TEX), a state of impaired effector functions. Typically, TEX has been characterized by high transcriptional and epigenetic reprogramming and increased expression of ...

“These epigenetic differences can be ... especially in solid tumor contexts, where exhaustion plays a large part in limiting anti-tumor T cell responses.” About the University of Colorado ...

This raises the questions of why T cell exhaustion exists, and whether disabling this mechanism in select T cells might offer a solution. Although immunotherapy is an approved therapy for a number ...

Debilitating chronic fatigue syndrome creates conditions where a kind of immune cell that identifies and kills pathogens, known as a T cell, becomes exhausted, according to a new study that points ...

Scientists from A*STAR Genome Institute of Singapore (A*STAR GIS) have uncovered that a key enzyme – P4HA1 prolyl hydroxylase, is strongly induced in CD8+ T cells in solid cancer, the primary immune ...