E6 associates with p53 and targets it for rapid degradation mediated by the ubiquitin ligase E6-associated protein (E6-AP), which does not recognize the free tumor suppressor. Inactivation of the ...

Edited by: Thomas W. Durso and Karen Young Kreeger M. Hochstrasser, "Ubiquitin, proteasomes, and the regulation of intracellular protein degradation," Current Opinion in Cell Biology, 7:215-23, 1995. ...

C-terminal amidation is a PTM that involves the addition of an amid group to the C-terminus of a peptide or protein. Currently there is no direct evidence to suggest that C-terminal amidation of ...

Here we explore peptide inhibitors of Cdc20, a substrate-recognition subunit and activator of the E3 ubiquitin ligase the anaphase promoting complex/cyclosome (APC/C) that is essential in mitosis and ...

Most of our prior work focused on the Ubl protein SUMO as it is essential in budding yeast and its conjugation to substrates requires an enzyme cascade that involves fewer factors in comparison to the ...

Frizzled (FZD) proteins are the principal receptors of the Wnt signaling pathway. However, whether Wnt ligands induce FZD endocytosis and degradation remains elusive. The transmembrane E3 ubiquitin ...

"The ubiquitin code can direct target proteins to specific cellular sites of action, activate them, trigger their incorporation into protein complexes or their degradation," explains Sonja Lorenz ...

My research specialties encompass the role that SUMO and ubiquitin play in protein degradation and the response to stress. Year of arrival: 2006, Professor College of William and Mary Previous ...

Whereas the PROTAC approach to target protein degradation greatly benefits from rational design ... While the human genome encodes over 600 E3 ubiquitin ligases, TPD is currently limited to the few ...

Unlike existing protein degradation therapies that target individual ... which can identify and degrade disordered proteins ...