Here we explore peptide inhibitors of Cdc20, a substrate-recognition subunit and activator of the E3 ubiquitin ligase the anaphase promoting complex/cyclosome (APC/C) that is essential in mitosis and ...

Viruses often manipulate ubiquitination pathways to facilitate ... key players in its interaction with CUL2 ZYG11B both in ITC assay and in vivo cells. In addition, enhancement of CUL2 ZYG11B ...

We develop chemical approaches for protein ubiquitination, activity-based Ub probes and inhibitors against deubiquitinases ... Cell Lysate-Based AlphaLISA Deubiquitinase Assay Platform for ...