In 2000, it was suggested to me that “Autophagy will be the wave of the future; it will become the new apoptosis.” Few people would have agreed at the time, but this statement turned out to be ...

Challenges remain, such as avoiding “traffic jams” caused by upstream autophagy enhancement in diseases with downstream defects. Furthermore, by uncovering the intricate links between aging ...

Recycling takes place in our cells at all times: in a process called autophagy, cell components that are no longer needed are enclosed by membranes and broken down into their basic building blocks.

Mitophagy is a selective form of autophagy via which the damaged mitochondria ... a whole-genome CRISPR-Cas9 screening to identify upstream regulators of PINK1-Parkin-mediated mitophagy.

SIGMAR1 is an integral membrane protein which activates an upstream compensatory process: Blarcamesine induces autophagy through SIGMAR1 activation resulting in restoring cellular homeostasis.