In the present study using cell lines, animal model and database analysis, we show that FMOD is crucial for breast cancer cell migration and invasion (BCCMI) via activation of ERK; expression of FMOD ...

Future research will therefore demonstrate how important the Wnt–β-catenin signalling pathway is for the self-renewal of cancer stem cells. The past two decades have seen a number of cases in ...

Dewpoint Therapeutics’ second development candidate, DPTX3496 is an oral, small molecule acting via a novel ...

Frizzled (FZD) proteins are the principal receptors of the Wnt signaling pathway. However, whether Wnt ligands induce FZD endocytosis and degradation remains elusive. The transmembrane E3 ubiquitin ...

Wnt 信号传导与促进体细胞重编程有关。然而，其分子机制仍不清楚。在这里，我们报告 Wnt/β-连环蛋白增强 iPSC 在重编程早期的诱导。 β-连环蛋白诱导的重编程增强并非由于细胞总数增加或 c-Myc 激活所致。此外，β-连环蛋白与重编程因子 Klf4、Oct4 和 Sox2 相互 ...

Proteins that can localize to the cilium, for example, Inversin and Bardet-Biedl syndrome (BBS) proteins, are implicated in both beta-catenin-dependent and -independent Wnt signalling ... study that ...

Molecular and cellular techniques were used to identify direct transcription target genes of Wnt/β-catenin signals. Microarray analyses and experiments that interfered with cell migration through ...

and to characterize molecular pathways triggered during Wnt signaling in this context (beta-catenin, calcium-dependent, planar cell polarity…). Particular attention will be given to articles studying ...

Background Aberrant Wnt pathway activation is a key driver of colorectal cancer (CRC ... Design We used global run-on sequencing to define β-catenin-regulated long non-coding RNAs (lncRNAs) in CRC.

WNT16 reduced the capacity of WNT3a to activate the canonical WNT pathway. In vivo, WNT16 rescued the WNT8-induced primary axis duplication in Xenopus embryos. Conclusions In osteoarthritis, WNT16 ...