Cancer therapeutics that target components of the canonical Wnt pathway. Recent studies suggest that so-called cancer stem cells, which represent only a minor fraction of tumour cells, might be ...

Frizzled (FZD) proteins are the principal receptors of the Wnt signaling pathway. However, whether Wnt ligands induce FZD endocytosis and degradation remains elusive. The transmembrane E3 ubiquitin ...

which provide WNT signals, and possibly also other signals. Importantly, these cells are the master regulators of the stem-like phenotype. Our group will elucidate the molecular mechanisms that ...

In a paper published March 21, 2013, in the journal Science, Nusse and his collaborators show that a protein called Wnt3a coordinates the orientation of the two different cell types that are generated ...

Dewpoint Therapeutics’ second development candidate, DPTX3496 is an oral, small molecule acting via a novel ...

Cancer Research UK, Cytovation, and the Norwegian Cancer Society collaborate to advance treatment for adrenocortical ...

Specific areas of interest are: The interplay of Wnt and Fgf family members in mammary gland development and breast cancer. Translational regulation as a new therapeutic ... metastases to ...

CD8 + T cells are crucial immune cells that possess ... nucleatum) can pose risks for colorectal cancer by activating the Wnt ...

CY-101, developed by Cytovation, is a synthetic peptide with a dual function. It selectively targets and destroys cancer cells, triggering a systemic immune response, while simultaneously inhibiting ...