Study reveals VLCFA metabolism as a key target in multiple myeloma, enhancing drug efficacy and overcoming resistance.

Scientists from CSIR-Central Drug Research Institute have discovered that targeting the enzyme acyl-CoA synthetase 4 (ACSL4) can help treat triple negative breast cancer (TNBC), which lacks ...

(acyl-CoA) availability. These modifications correlate with metabolic states, impacting chromatin accessibility and transcription. SCFAs, such as propionate and butyrate, derived from dietary ...

Despite the difficult road she's faced in her short life, Evie's smile shines through as a testament to the strength of her ...

short-chain lysine acylations like propionylation (Kpr) and butyrylation (Kbu) link metabolism to gene regulation via acyl-coenzyme A. (acyl-CoA) availability. Read the full story here.