From being a promising yet underexplored approach in the 1990s, mRNA therapeutics have evolved dramatically. The discovery of ...

In particular, sRNAs could be generated by RNAPIIs that initiate transcription in the vicinity of, but not at, the correct mRNA TSS and that terminate prematurely, before they switch to the ...

Messenger RNA abundance is determined by balancing transcription and RNA decay. mRNA stability can be rapidly modulated to alter the expression of specific genes thereby providing flexibility in ...

InDevR partners with Aldevron to describe how the VaxArray 5′CapQ assay can be used to measure intact mRNA in a single assay to streamline bioprocess development.

The journey of mRNA begins in the cell nucleus, where it is synthesized through a process called transcription: Through this process, mRNA serves as the critical link between the genetic information ...

BRM (Probableglobal transcription activator SNF2L2) ...

Thus, transcription-factor proteins can bind to several different sections of the gene and begin making mRNA, each copy different from ones started at other sites.

2 Located throughout the pre-mRNA are short, cis-acting motifs consisting of five to six nucleotides that are binding sites for RBP, which act in trans. 1,8 “When an exon that is alternatively spliced ...

Specifically, we investigate how 3′UTRs regulate protein functions in a manner that is independent of protein abundance. We found that inclusion or exclusion of the 3′UTR of an mRNA that encodes a ...

templates for in vitro transcription (IVT) synthesis of mRNA molecules. Alchemy cell-free DNA technology is now available at research grade, providing researchers with a faster, more efficient ...

Aldevron’s Alchemy™ is an exclusive cell-free DNA technology which cuts research grade linear DNA manufacturing time by over ...

This process of protein synthesis occurs in two stages - transcription and translation. When a gene is to be expressed, the base sequence of DNA is copied or transcribed into mRNA (messenger RNA).