tRNAs are highly conserved across all domains of life, from bacteria to archaea and eukaryotes. This evolutionary conservation highlights the fundamental role of tRNA in the essential process of ...

The structure resolves some mechanistic questions and allows for comparison of the tRNA-dependent synthesis of cysteine and selenocysteine.

If Pnkp and Rnl1 are not present, depletion of the pool of functional tRNA Lys by PrrC blocks phage protein synthesis and arrests the infection before it can spread. However, Pnkp and Rnl1 repair the ...

Methylation of mRNA leads to a change to its chemical structure so that it can no longer correctly interact with tRNA. "The synthesis process is undermined, and fewer proteins of the subunit ND5 ...

The findings reveal how the absence of TRMT10A leads to a reduction in specific transfer RNA (tRNA) levels, disrupting ...

To ensure accurate translation, tRNA molecules undergo various post-transcriptional modifications, particularly in the anticodon region. These modifications can influence codon recognition, ...

Retroviruses are a sub-category of oncoviruses that include the lentiviruses. Retroviruses are negative single-stranded RNA viruses in which tRNA serves as a primer for the mRNA synthesis. The mRNA is ...

scientists described the action mechanism of a toxin that blocks protein synthesis and demonstrated how the cell could detoxify itself. These findings pave the way for developing treatments based on ...