Cancer remains one of the most complex diseases, with its diverse molecular profiles and cellular compositions posing ...

While these organoids are derived from cancer cell lines and don’t accurately recapitulate the complexity of the tumor microenvironment, the team plans to test their approach using patient-derived ...

While comparing mechanical dissociation and enzymatic digestion for generating patient-derived organoids (PDOs), they emphasize the importance of maintaining the tumor microenvironment ...

An immuno-oncology targeting panel accurately characterized tumor-resident immune cells and located pathologically and clinically relevant tumor microenvironment features. Cancer development and ...

A team led by researchers at the Technical University of Munich (TUM) has, for the first time, grown tumor organoids – three-dimensional miniature tumors in the laboratory – that mimic the ...

they built a large-scale library of tongue cancer organoids (TCOs) from surgery samples of 28 patients. Organoids are three-dimensional tissue models that mimic organs. As explained in their paper ...

Tongue cancer (TC) cells can enter a chemo-resistant state by activating pathways related to autophagy and cholesterol synthesis, report researchers. Using a large-scale library of TC organoids ...

When individual tumor cells are isolated and used to grow artificial 3D cell clusters in the laboratory, referred to as organoids, the conventional approach produces only spherical-like structures.

The Mara Sherman lab aims to understand the heterocellular interactions among pancreatic cancer cells and their surrounding microenvironment, and to target these networks for therapeutic benefit. Our ...