Background and aims The transcription factor sex-determining region Y-related high-mobility group-box gene 9 (SOX9) plays a critical role in organ development. Although SOX9 has been implicated in ...

The bile acid activates AMP-activated protein kinase. “The discovery of LCA as a metabolic mediator of calorie restriction, and its effects across biochemical, cellular, and organismal levels, is ...

Previous research has shown that mammals accumulate LCA during calorie restriction and it activates a key molecule involved in metabolism called AMP-activated protein kinase, or AMPK. AMPK ...