Drugs that specifically inhibit BCR signaling elements ... receptor-activation pathways following antigenic stimulation. BCR: B-cell receptor; BLNK: B-cell linker protein; BTK: Bruton's tyrosine ...

Disparate pathogenic mechanisms complicate precision-medicine efforts to treat diffuse large B-cell lymphoma (DLBCL), the most common lymphoma diagnosis. Though potentially curable with frontline ...

Targeting SRC-3, therefore, can impact many cancer signaling pathways simultaneously and may alleviate drug resistance problem ... affects the degradation of Bruton’s Tyrosine Kinase (BTK), we ...

BTK inhibitors, including the commonly used drug ibrutinib, block B cells' signaling pathway. This is helpful for treating B-cell lymphomas because the cancers arise when this signaling pathway ...