Sarcomeric myosin heavy chain proteins are the molecular motors responsible for muscle contraction. Mutations in these proteins perturb their interactions with other proteins and their function, which ...

Calcium handling and excitation-contraction (EC) coupling are critical processes in cardiac myocytes, the muscle cells of the ... has focused on the intricate mechanisms that govern calcium ...

Smooth muscle contraction is a vital physiological process ... Recent research has expanded our understanding of these mechanisms, revealing the involvement of various kinases and phosphatases ...

Proper contraction and relaxation of the heart depends on the coordinated flux of calcium ions in and out of individual cardiac muscle cells. Research in our lab focuses on understanding ...

We employ single molecule fluorescence techniques and laser trapping assays to study: the mechanism and regulation muscle contraction, cell motility, and the regulation of cell shape. Our lab’s ...