We employ single molecule fluorescence techniques and laser trapping assays to study: the mechanism and regulation muscle contraction, cell motility, and the regulation of cell shape. Our lab’s ...

Recent research has focused on understanding the molecular mechanisms ... up the heart muscle, particularly those in the sarcomere, which is the fundamental unit of muscle contraction.

Calcium handling and excitation-contraction (EC) coupling are critical processes in cardiac myocytes, the muscle cells of the ... has focused on the intricate mechanisms that govern calcium ...

Numerous motor and structural proteins compose a highly ordered structure known as the sarcomere, the basic unit of muscle contraction in heart and skeletal ... Research in the Leinwand lab focuses on ...