When the fork stalls due to an obstacle on the DNA (Figure 1), the cell activates the replication checkpoint to send a signal to arrest the progression of the cell cycle. Another example of ...

How cells respond to mitochondrial DNA (mtDNA) damage is not fully understood. This study uncovers a mechanism of mtDNA ...

While the multiciliation cycle followed the transcriptional phases of the traditional cell cycle, DNA replication did not occur and the cells did not end up dividing. Instead, they grew a bunch of ...

A team has unearthed new findings about what happens during the minutes and hours after a cell divides, expanding our understanding of human biology -- and potentially leading to better medicines.

The precision of this process depends in large measure upon stringent regulatory mechanisms that couple DNA replication to cell cycle progression. Initiation must be triggered at the appropriate time ...

Replication of DNA DNA replication is the process by which a cell makes an identical copy of its DNA. Gene expression Only a fraction of the genes possessed by any particular cell will be expressed.

We also discovered that this breakage mechanism only occurs at the beginning of the cell cycle phase, when DNA replication ...