Crucially, key literature relevant to this research, addressing the role of ICAM1 endocytosis in antigen-presenting cells, has not been taken into consideration. The manuscript by Xu et al. studies ...

Immunostimulant therapy using agonistic cytokines or activating antibodies has been associated with off-target side effects, failure to preferentially activate cytotoxic lymphocytes (CTLs) over ...

Cytotoxic T cells are CD8-postive T cells that are specialized for the direct killing of cells that are infected (particularly with viruses), cancerous or damaged in other ways. They express the ...

The antibody has shown promising results in preclinical studies, demonstrating 'superior' anti-tumour activity.

The cytotoxic CD8+ and γδ+ T cell response in the epithelium is thought to ... Common pathways upregulated in coeliac disease included those involved in the regulation of cell activation and adhesion, ...

A recent study revealed that most γδ T cells resident in pre-malignant or non-tumor colon tissues host a cytotoxic signature, while the γδ T cells infiltrated ... then shape early adaptive immune ...

DelveInsight’s, “Mesothelioma Pipeline Insight 2025” report provides comprehensive insights about 45+ companies and 50+ ...

In the present study, we show that CD8 + CCR4 + T cells isolated from patients in an active state of the disease display an altered phenotype with a distinct cytotoxic and transcriptomic profile, ...