although various other partly deuterated benzenes, together with hexadeuterobenzene, had been examined. The s-tri-derivative has now been made (m.p. 6·1°).

The next-generation therapy introduces vanzacaftor, a novel corrector, and deutivacaftor, a deuterated analogue of Vertex’s first-in-class potentiator ivacaftor. Deutivacaftor, previously called ...