This paper reports important findings on giant organelle complexes containing endosomes and lysosomes (termed endosomal-lysosomal organelles form assembly structures [ELYSAs]) present in mouse oocytes ...

Although these structures have often been observed in oocytes and early embryos, their exact nature has not been characterized. The authors named these structures "endosomal-lysosomal organelles form ...

Finally, the discovery of the CROP complex, which mediates membrane fission in the endo-lysosomal system, adds another layer of complexity to our understanding of endosomal dynamics. This complex ...

Acid-sensitive nanoparticles that are prone to swelling, dissolution or degradation at endosomal/lysosomal pH have been devised to obtain fast intracellular doxorubicin release in the tumor cells.

SORL1 dysfunction messes with endosomes in neurons, and with lysosomes in microglia.

Jan. 15, 2025 — New observational data and simulation models have confirmed a new type of planet unlike anything found in the Solar System. This provides another piece of the puzzle to ...

GM1 gangliosidosis and GM2 gangliosidosis (Tay-Sachs and Sandhoff diseases) are lysosomal storage disorders caused by the accumulation of GM1 or GM2 gangliosides respectively, in the central nervous ...

are lysosomal storage disorders caused by the accumulation of GM1 or GM2 gangliosides respectively, in the central nervous system (CNS), resulting in progressive and severe neurological impairment ...

Faculty of Life Sciences, Department of Pharmaceutical Sciences, Laboratory of Macromolecular Cancer Therapeutics (MMCT), University of Vienna, Josef-Holaubek-Platz 2, 1090 Vienna, Austria ...